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Research Description:

Dr. Ganaie’s laboratory focuses on elucidating the molecular mechanisms of host-pathogen interactions that facilitate virus entry, infection, and pathogenesis, with a primary emphasis on Bunyaviruses—highly pathogenic, BSL-2 and BSL-3, negative-strand RNA viruses. His research takes a multidisciplinary approach, integrating genetic, biochemical, biophysical, and in vivo (mouse) model systems to dissect the complexities of bunyaviral infection pathways and the host-virus interface. His recent studies identified LRP1 as a receptor for Rift Valley Fever Virus and clarified its role in the infection mechanisms of other RNA viruses. These findings significantly advance the understanding of RNA virus biology and pave the way for developing innovative antiviral therapeutics targeting a broad spectrum of RNA viruses.

Topics of Interest:

• Emerging & Re-emerging RNA Viruses
• Viral entry and infection
• Viral Pathogenesis
• Arboviruses
• Genome-wide CRSIPR Screens

Lab Room Information:

• Lab Room: ARB- R1-281
• Lab Phone: 352-273-6380